1dp5

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[[Image:1dp5.gif|left|200px]]
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{{Seed}}
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[[Image:1dp5.png|left|200px]]
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{{STRUCTURE_1dp5| PDB=1dp5 | SCENE= }}
{{STRUCTURE_1dp5| PDB=1dp5 | SCENE= }}
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'''THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR'''
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===THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR===
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==Overview==
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Aspartic proteinase A from yeast is specifically and potently inhibited by a small protein called IA3 from Saccharomyces cerevisiae. Although this inhibitor consists of 68 residues, we show that the inhibitory activity resides within the N-terminal half of the molecule. Structures solved at 2.2 and 1.8 A, respectively, for complexes of proteinase A with full-length IA3 and with a truncated form consisting only of residues 2-34, reveal an unprecedented mode of inhibitor-enzyme interactions. Neither form of the free inhibitor has detectable intrinsic secondary structure in solution. However, upon contact with the enzyme, residues 2-32 become ordered and adopt a near-perfect alpha-helical conformation. Thus, the proteinase acts as a folding template, stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 10655612 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10655612}}
==About this Structure==
==About this Structure==
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[[Category: Mmm]]
[[Category: Mmm]]
[[Category: Proteinase some]]
[[Category: Proteinase some]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:06:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:24:21 2008''

Revision as of 20:24, 30 June 2008

Image:1dp5.png

Template:STRUCTURE 1dp5

THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR

Template:ABSTRACT PUBMED 10655612

About this Structure

1DP5 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix., Li M, Phylip LH, Lees WE, Winther JR, Dunn BM, Wlodawer A, Kay J, Gustchina A, Nat Struct Biol. 2000 Feb;7(2):113-7. PMID:10655612

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