1dp8

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{{STRUCTURE_1dp8| PDB=1dp8 | SCENE= }}
{{STRUCTURE_1dp8| PDB=1dp8 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE NITRIC OXIDE BOUND FIXL HEME DOMAIN'''
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===CRYSTAL STRUCTURE OF THE NITRIC OXIDE BOUND FIXL HEME DOMAIN===
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==Overview==
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The FixL heme domain serves as the dioxygen switch in the FixL/FixJ two-component system of Rhizobia. Recent structural studies of the Bradyrhizobium japonicum FixL heme domain (BjFixLH) have suggested an allosteric mechanism that is distinct from the classical hemoglobin model. To gain further insight into the FixL sensing mechanism, structures of BjFixLH bound to dioxygen, imidazole, and nitric oxide have been determined. These structures, particularly the structure of BjFixLH bound to its physiological ligand, dioxygen, have helped to address a number of important issues relevant to the BjFixLH sensing mechanism. On the basis of the oxy-BjFixLH structure, a conserved arginine is found to stabilize the dioxygen ligand in a mode reminiscent of the distal histidine in classical myoglobins and hemoglobins. The structure of BjFixLH bound to imidazole elucidates the structural requirements for accommodating sterically bulky ligands. Finally, the structure of BjFixLH bound to nitric oxide provides evidence for a structural intermediate in the heme-driven conformational change.
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{{ABSTRACT_PUBMED_10747783}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Two component system]]
[[Category: Two component system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:06:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:24:35 2008''

Revision as of 20:24, 30 June 2008

Image:1dp8.png

Template:STRUCTURE 1dp8

CRYSTAL STRUCTURE OF THE NITRIC OXIDE BOUND FIXL HEME DOMAIN

Template:ABSTRACT PUBMED 10747783

About this Structure

1DP8 is a Single protein structure of sequence from Bradyrhizobium japonicum. Full crystallographic information is available from OCA.

Reference

New mechanistic insights from structural studies of the oxygen-sensing domain of Bradyrhizobium japonicum FixL., Gong W, Hao B, Chan MK, Biochemistry. 2000 Apr 11;39(14):3955-62. PMID:10747783

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