1dp7

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[[Image:1dp7.gif|left|200px]]
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{{STRUCTURE_1dp7| PDB=1dp7 | SCENE= }}
{{STRUCTURE_1dp7| PDB=1dp7 | SCENE= }}
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'''COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE'''
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===COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE===
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==Overview==
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Regulatory factor X (RFX) proteins are transcriptional activators that recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD). DNA-binding defects in the protein RFX5 cause bare lymphocyte syndrome or major histocompatibility antigen class II deficiency. RFX1, -2 and -3 regulate expression of other medically important gene products (for example, interleukin-5 receptor alpha chain, IL-5R alpha). Fusions of the ligand-binding domain of the oestrogen receptor with the DBD of RFX4 occur in some human breast tumours. Here we present a 1.5 A-resolution structure of two copies of the DBD of human RFX1 (hRFX1) binding cooperatively to a symmetrical X-box. hRFX1 is an unusual member of the winged-helix subfamily of helix-turn-helix proteins because it uses a beta-hairpin (or wing) to recognize DNA instead of the recognition helix typical of helix-turn-helix proteins. A new model for interactions between linker histones and DNA is proposed.
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(as it appears on PubMed at http://www.pubmed.gov), where 10706293 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10706293}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna cocrystal structure]]
[[Category: Protein-dna cocrystal structure]]
[[Category: Winged helix]]
[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:06:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:24:38 2008''

Revision as of 20:24, 30 June 2008

Image:1dp7.png

Template:STRUCTURE 1dp7

COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE

Template:ABSTRACT PUBMED 10706293

About this Structure

1DP7 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding., Gajiwala KS, Chen H, Cornille F, Roques BP, Reith W, Mach B, Burley SK, Nature. 2000 Feb 24;403(6772):916-21. PMID:10706293

Page seeded by OCA on Mon Jun 30 23:24:38 2008

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