1dpf

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{{STRUCTURE_1dpf| PDB=1dpf | SCENE= }}
{{STRUCTURE_1dpf| PDB=1dpf | SCENE= }}
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'''CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP'''
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===CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP===
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==Overview==
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Mg(2+) ions are essential for guanosine triphosphatase (GTPase) activity and play key roles in guanine nucleotide binding and preserving the structural integrity of GTP-binding proteins. We determined the crystal structure of a small GTPase RHOA complexed with GDP in the absence of Mg(2+) at 2.0-A resolution. Elimination of a Mg(2+) ion induces significant conformational changes in the switch I region that opens up the nucleotide-binding site. Similar structural changes have been observed in the switch regions of Ha-Ras bound to its guanine nucleotide exchange factor, Sos. This RHOA-GDP structure reveals an important regulatory role for Mg(2+) and suggests that guanine nucleotide exchange factor may utilize this feature of switch I to produce an open conformation in GDP/GTP exchange.
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(as it appears on PubMed at http://www.pubmed.gov), where 10748207 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10748207}}
==About this Structure==
==About this Structure==
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[[Category: Shimizu, T.]]
[[Category: Shimizu, T.]]
[[Category: Protein rhoa-gdp complex]]
[[Category: Protein rhoa-gdp complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:25:07 2008''

Revision as of 20:25, 30 June 2008

Image:1dpf.png

Template:STRUCTURE 1dpf

CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP

Template:ABSTRACT PUBMED 10748207

About this Structure

1DPF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism., Shimizu T, Ihara K, Maesaki R, Kuroda S, Kaibuchi K, Hakoshima T, J Biol Chem. 2000 Jun 16;275(24):18311-7. PMID:10748207

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