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1dpq

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[[Image:1dpq.jpg|left|200px]]
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[[Image:1dpq.png|left|200px]]
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{{STRUCTURE_1dpq| PDB=1dpq | SCENE= }}
{{STRUCTURE_1dpq| PDB=1dpq | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CONSTITUTIVELY ACTIVE MUTANT OF THE INTEGRIN ALPHA IIB CYTOPLASMIC DOMAIN.'''
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===SOLUTION STRUCTURE OF THE CONSTITUTIVELY ACTIVE MUTANT OF THE INTEGRIN ALPHA IIB CYTOPLASMIC DOMAIN.===
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==Overview==
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A key step in the activation of heterodimeric integrin adhesion receptors is the transmission of an agonist-induced cellular signal from the short alpha- and/or beta-cytoplasmic tails to the extracellular domains of the receptor. The structural details of how the cytoplasmic tails mediate such an inside-out signaling process remain unclear. We report herein the NMR structures of a membrane-anchored cytoplasmic tail of the alpha(IIb)-subunit and of a mutant alpha(IIb)-cytoplasmic tail that renders platelet integrin alpha(IIb)beta(3) constitutively active. The structure of the wild-type alpha(IIb)-cytoplasmic tail reveals a "closed" conformation where the highly conserved N-terminal membrane-proximal region forms an alpha-helix followed by a turn, and the acidic C-terminal loop interacts with the N-terminal helix. The structure of the active mutant is significantly different, having an "open" conformation where the interactions between the N-terminal helix and C-terminal region are abolished. Consistent with these structural differences, the two peptides differ in function: the wild-type peptide suppressed alpha(IIb)beta(3) activation, whereas the mutant peptide did not. These results provide an atomic explanation for extensive biochemical/mutational data and support a conformation-based "on/off switch" model for integrin activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_10677482}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10677482 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10677482}}
==About this Structure==
==About this Structure==
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1DPQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPQ OCA].
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1DPQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPQ OCA].
==Reference==
==Reference==
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[[Category: Vinogradova, O.]]
[[Category: Vinogradova, O.]]
[[Category: Helix]]
[[Category: Helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:07:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:25:59 2008''

Revision as of 20:26, 30 June 2008

Image:1dpq.png

Template:STRUCTURE 1dpq

SOLUTION STRUCTURE OF THE CONSTITUTIVELY ACTIVE MUTANT OF THE INTEGRIN ALPHA IIB CYTOPLASMIC DOMAIN.

Template:ABSTRACT PUBMED 10677482

About this Structure

1DPQ is a Single protein structure. Full experimental information is available from OCA.

Reference

A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit., Vinogradova O, Haas T, Plow EF, Qin J, Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1450-5. PMID:10677482

Page seeded by OCA on Mon Jun 30 23:25:59 2008

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