This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dqb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dqb.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1dqb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dqb| PDB=1dqb | SCENE= }}
{{STRUCTURE_1dqb| PDB=1dqb | SCENE= }}
-
'''NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)'''
+
===NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)===
-
==Overview==
+
<!--
-
A glycosylated fragment of thrombomodulin containing two epidermal growth factor-like domains (TMEGF45) was analyzed by NMR. The 4th-domains structure of this two-domain fragment is similar to that of the individual domain previously determined. The 5th-domain, which has uncrossed disulfide bonds, is not as well determined in the two-domain fragment than the individual domain previously solved. The flexibility of the 5th-domain is consistent with low heteronuclear NOEs. In the individual 5th-domain, Met 388 was disordered, and key thrombin binding residues formed a hydrophobic core. By contrast, in TMEGF45, Met 388 is in the 5th-domain core, positioned by Phe 376 from the 4th-domain. As a result, key thrombin binding residues that were in the core of the individual domain are expelled. Upon thrombin binding, chemical shifts of two residues in the 4th-domain, the three interdomain linker residues, and nearly all of the 5th-domain are perturbed. Thus, TMEGF45 binds thrombin by an induced fit mechanism involving a flexible 5th-domain.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10700277}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10700277 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10700277}}
==About this Structure==
==About this Structure==
-
1DQB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQB OCA].
+
1DQB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DQB OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Thrombin]]
[[Category: Thrombin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:08:59 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:27:28 2008''

Revision as of 20:27, 30 June 2008

Image:1dqb.png

Template:STRUCTURE 1dqb

NMR STRUCTURE OF THROMBOMODULIN EGF(4-5)

Template:ABSTRACT PUBMED 10700277

About this Structure

1DQB is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the smallest cofactor-active fragment of thrombomodulin., Wood MJ, Sampoli Benitez BA, Komives EA, Nat Struct Biol. 2000 Mar;7(3):200-4. PMID:10700277

Page seeded by OCA on Mon Jun 30 23:27:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dqb"
Personal tools