1dqt

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[[Image:1dqt.gif|left|200px]]
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{{Seed}}
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[[Image:1dqt.png|left|200px]]
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{{STRUCTURE_1dqt| PDB=1dqt | SCENE= }}
{{STRUCTURE_1dqt| PDB=1dqt | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)'''
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===THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)===
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==Overview==
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The effective regulation of T cell responses is dependent on opposing signals transmitted through two related cell-surface receptors, CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Dimerization of CTLA-4 is required for the formation of high-avidity complexes with B7 ligands and for transmission of signals that attenuate T cell activation. We determined the crystal structure of the extracellular portion of CTLA-4 to 2.0 angstrom resolution. CTLA-4 belongs to the immunoglobulin superfamily and displays a strand topology similar to Valpha domains, with an unusual mode of dimerization that places the B7 binding sites distal to the dimerization interface. This organization allows each CTLA-4 dimer to bind two bivalent B7 molecules and suggests that a periodic arrangement of these components within the immunological synapse may contribute to the regulation of T cell responsiveness.
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The line below this paragraph, {{ABSTRACT_PUBMED_11052947}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11052947 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11052947}}
==About this Structure==
==About this Structure==
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[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Immunoglobulin variable domain-like beta-sandwich]]
[[Category: Immunoglobulin variable domain-like beta-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:10:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:28:57 2008''

Revision as of 20:28, 30 June 2008

Image:1dqt.png

Template:STRUCTURE 1dqt

THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)

Template:ABSTRACT PUBMED 11052947

About this Structure

1DQT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of murine CTLA-4 and its role in modulating T cell responsiveness., Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG, Science. 2000 Oct 27;290(5492):816-9. PMID:11052947

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