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1drs

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[[Image:1drs.gif|left|200px]]
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{{Seed}}
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[[Image:1drs.png|left|200px]]
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{{STRUCTURE_1drs| PDB=1drs | SCENE= }}
{{STRUCTURE_1drs| PDB=1drs | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN'''
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===THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN===
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==Overview==
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Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
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The line below this paragraph, {{ABSTRACT_PUBMED_7634091}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7634091 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7634091}}
==About this Structure==
==About this Structure==
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1DRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].
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1DRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].
==Reference==
==Reference==
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[[Category: Williams, J A.]]
[[Category: Williams, J A.]]
[[Category: Cell adhesion protein]]
[[Category: Cell adhesion protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:11:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:31:08 2008''

Revision as of 20:31, 30 June 2008

Image:1drs.png

Template:STRUCTURE 1drs

THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN

Template:ABSTRACT PUBMED 7634091

About this Structure

1DRS is a Single protein structure of sequence from Dendroaspis jamesoni kaimosae. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin., Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA, Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091

Page seeded by OCA on Mon Jun 30 23:31:08 2008

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