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1drz

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{{Seed}}
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{{STRUCTURE_1drz| PDB=1drz | SCENE= }}
{{STRUCTURE_1drz| PDB=1drz | SCENE= }}
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'''U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX'''
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===U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX===
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==Overview==
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The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 9783582 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9783582}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
[[Category: U1a]]
[[Category: U1a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:12:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:31:33 2008''

Revision as of 20:31, 30 June 2008

Image:1drz.png

Template:STRUCTURE 1drz

U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX

Template:ABSTRACT PUBMED 9783582

About this Structure

1DRZ is a Single protein structure of sequence from Hepatitis delta virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:9783582

Page seeded by OCA on Mon Jun 30 23:31:33 2008

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