1dth

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dth.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1dth.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1dth| PDB=1dth | SCENE= }}
{{STRUCTURE_1dth| PDB=1dth | SCENE= }}
-
'''METALLOPROTEASE'''
+
===METALLOPROTEASE===
-
==Overview==
+
<!--
-
Matrix metalloproteinase enzymes have been implicated in degenerative processes like tumor cell invasion, metastasis, and arthritis. Specific metalloproteinase inhibitors have been used to block tumor cell proliferation. We have examined the interaction of batimastat (BB-94) with a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. This unprecedented binding geometry dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor drugs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8610113}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8610113 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8610113}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Venom]]
[[Category: Venom]]
[[Category: Zinc]]
[[Category: Zinc]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:15:17 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:35:26 2008''

Revision as of 20:35, 30 June 2008

Image:1dth.png

Template:STRUCTURE 1dth

METALLOPROTEASE

Template:ABSTRACT PUBMED 8610113

About this Structure

1DTH is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding., Botos I, Scapozza L, Zhang D, Liotta LA, Meyer EF, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. PMID:8610113

Page seeded by OCA on Mon Jun 30 23:35:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dth"
Personal tools