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1du3

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[[Image:1du3.gif|left|200px]]
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{{Seed}}
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[[Image:1du3.png|left|200px]]
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{{STRUCTURE_1du3| PDB=1du3 | SCENE= }}
{{STRUCTURE_1du3| PDB=1du3 | SCENE= }}
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'''Crystal structure of TRAIL-SDR5'''
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===Crystal structure of TRAIL-SDR5===
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==Overview==
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TRAIL is a cytokine that induces apoptosis in a wide variety of tumor cells but rarely in normal cells. It contains an extraordinarily elongated loop because of an unique insertion of 12-16 amino acids compared with the other members of tumor necrosis factor family. Biological implication of the frame insertion has not been clarified. We have determined the crystal structure of TRAIL in a complex with the extracellular domain of death receptor DR5 at 2.2 A resolution. The structure reveals extensive contacts between the elongated loop and DR5 in an interaction mode that would not be allowed without the frame insertion. These interactions are missing in the structures of the complex determined by others recently. This observation, along with structure-inspired deletion analysis, identifies the critical role of the frame insertion as a molecular strategy conferring specificity upon the recognition of cognate receptors. The structure also suggests that a built-in flexibility of the tumor necrosis factor receptor family members is likely to play a general and important role in the binding and recognition of tumor necrosis factor family members.
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The line below this paragraph, {{ABSTRACT_PUBMED_10893238}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10893238 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10893238}}
==About this Structure==
==About this Structure==
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[[Category: Dr5]]
[[Category: Dr5]]
[[Category: Trail]]
[[Category: Trail]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:16:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:37:14 2008''

Revision as of 20:37, 30 June 2008

Image:1du3.png

Template:STRUCTURE 1du3

Crystal structure of TRAIL-SDR5

Template:ABSTRACT PUBMED 10893238

About this Structure

1DU3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of TRAIL-DR5 complex identifies a critical role of the unique frame insertion in conferring recognition specificity., Cha SS, Sung BJ, Kim YA, Song YL, Kim HJ, Kim S, Lee MS, Oh BH, J Biol Chem. 2000 Oct 6;275(40):31171-7. PMID:10893238

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