1du6

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{{STRUCTURE_1du6| PDB=1du6 | SCENE= }}
{{STRUCTURE_1du6| PDB=1du6 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN'''
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===SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN===
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==Overview==
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PBX is a member of the three amino acid loop extension (TALE) class of homeodomains. PBX binds DNA cooperatively with HOX homeodomain proteins that contain a conserved YPWM motif. The amino acids immediately C-terminal to the PBX homeodomain increase the affinity of the homeodomain for its DNA site and HOX proteins. We have determined the structure of the free PBX homeodomain using NMR spectroscopy. Both the PBX homeodomain and the extended PBX homeodomain make identical contacts with a 5'-TGAT-3' DNA site and a YPWM peptide. A fourth alpha-helix, which forms upon binding to DNA, stabilizes the extended PBX structure. Variations in DNA sequence selectivity of heterodimeric PBX-HOX complexes depend on the HOX partner; however, a comparison of five different HOX-derived YPWM peptides showed that each bound to PBX in the same way, differing only in the strength of the association.
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(as it appears on PubMed at http://www.pubmed.gov), where 10933814 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10933814}}
==About this Structure==
==About this Structure==
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1DU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DU6 OCA].
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1DU6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DU6 OCA].
==Reference==
==Reference==
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[[Category: Sprules, T.]]
[[Category: Sprules, T.]]
[[Category: Homeodomain]]
[[Category: Homeodomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:16:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:37:18 2008''

Revision as of 20:37, 30 June 2008

Image:1du6.png

Template:STRUCTURE 1du6

SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN

Template:ABSTRACT PUBMED 10933814

About this Structure

1DU6 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Conformational changes in the PBX homeodomain and C-terminal extension upon binding DNA and HOX-derived YPWM peptides., Sprules T, Green N, Featherstone M, Gehring K, Biochemistry. 2000 Aug 15;39(32):9943-50. PMID:10933814

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