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1dud

From Proteopedia

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{{STRUCTURE_1dud| PDB=1dud | SCENE= }}
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'''DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)'''
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===DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)===
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==Overview==
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We have determined the structure of the homotrimeric dUTPase from Escherichia coli, completed with an inhibitor and substrate analogue, dUDP. Three molecules of dUDP are found symmetrically bound per trimer, each in a shallow cleft between adjacent subunits, interacting with evolutionary conserved residues. The interactions of the uracil ring and the deoxypentose with the protein are consistent with the high specificity of the enzyme with respect to these groups. The positions of the two phosphate groups and adjacent water molecules are discussed in relation to the mechanism and kinetics of catalysis. The role that dUTPase plays in DNA metabolism makes the enzyme a potential target for chemotherapeutic drugs: the results presented here will aid in the design and development of inhibitory compounds.
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(as it appears on PubMed at http://www.pubmed.gov), where 8646539 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8646539}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide metabolism]]
[[Category: Nucleotide metabolism]]
[[Category: Substrate analogue]]
[[Category: Substrate analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:17:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:37:47 2008''

Revision as of 20:37, 30 June 2008

Image:1dud.png

Template:STRUCTURE 1dud

DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDE HYDROLASE (D-UTPASE) COMPLEXED WITH THE SUBSTRATE ANALOGUE DEOXYURIDINE 5'-DIPHOSPHATE (D-UDP)

Template:ABSTRACT PUBMED 8646539

About this Structure

1DUD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Escherichia coli dUTPase in complex with a substrate analogue (dUDP)., Larsson G, Svensson LA, Nyman PO, Nat Struct Biol. 1996 Jun;3(6):532-8. PMID:8646539

Page seeded by OCA on Mon Jun 30 23:37:47 2008

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