1duj

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[[Image:1duj.jpg|left|200px]]
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{{Seed}}
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[[Image:1duj.png|left|200px]]
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{{STRUCTURE_1duj| PDB=1duj | SCENE= }}
{{STRUCTURE_1duj| PDB=1duj | SCENE= }}
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'''SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2'''
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===SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2===
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==Overview==
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The checkpoint protein Mad2 inhibits the activity of the anaphase promoting complex by sequestering Cdc20 until all chromosomes are aligned at the metaphase plate. We report the solution structure of human Mad2 and its interaction with Cdc20. Mad2 possesses a novel three-layered alpha/beta fold with three alpha-helices packed between two beta-sheets. Using deletion mutants we identified the minimal Mad2-binding region of human Cdc20 as a 40-residue segment immediately N-terminal to the WD40 repeats. Mutagenesis and NMR titration experiments show that a C-terminal flexible region of Mad2 is required for binding to Cdc20. Mad2 and Cdc20 form a tight 1:1 heterodimeric complex in which the C-terminal segment of Mad2 becomes folded. These results provide the first structural insight into mechanisms of the spindle assembly checkpoint.
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The line below this paragraph, {{ABSTRACT_PUBMED_10700282}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10700282 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10700282}}
==About this Structure==
==About this Structure==
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1DUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUJ OCA].
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1DUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUJ OCA].
==Reference==
==Reference==
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[[Category: Mad2]]
[[Category: Mad2]]
[[Category: Spindle assembly checkpoint]]
[[Category: Spindle assembly checkpoint]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:17:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:38:15 2008''

Revision as of 20:38, 30 June 2008

Image:1duj.png

Template:STRUCTURE 1duj

SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2

Template:ABSTRACT PUBMED 10700282

About this Structure

1DUJ is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20., Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G, Nat Struct Biol. 2000 Mar;7(3):224-9. PMID:10700282

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