1duq

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[[Image:1duq.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1duq| PDB=1duq | SCENE= }}
{{STRUCTURE_1duq| PDB=1duq | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1'''
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===CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1===
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==Overview==
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The crystal and molecular structure of an RNA duplex corresponding to the high affinity Rev protein binding element (RBE) has been determined at 2.1-A resolution. Four unique duplexes are present in the crystal, comprising two structural variants. In each duplex, the RNA double helix consists of an annealed 12-mer and 14-mer that form an asymmetric internal loop consisting of G-G and G-A noncanonical base pairs and a flipped-out uridine. The 12-mer strand has an A-form conformation, whereas the 14-mer strand is distorted to accommodate the bulges and noncanonical base pairing. In contrast to the NMR model of the unbound RBE, an asymmetric G-G pair with N2-N7 and N1-O6 hydrogen bonding, is formed in each helix. The G-A base pairing agrees with the NMR structure in one structural variant, but forms a novel water-mediated pair in the other. A backbone flip and reorientation of the G-G base pair is required to assume the RBE conformation present in the NMR model of the complex between the RBE and the Rev peptide.
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The line below this paragraph, {{ABSTRACT_PUBMED_10792052}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10792052 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10792052}}
==About this Structure==
==About this Structure==
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[[Category: Rev binding domain]]
[[Category: Rev binding domain]]
[[Category: Rre]]
[[Category: Rre]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:18:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:38:49 2008''

Revision as of 20:38, 30 June 2008

Image:1duq.png

Template:STRUCTURE 1duq

CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1

Template:ABSTRACT PUBMED 10792052

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability., Hung LW, Holbrook EL, Holbrook SR, Proc Natl Acad Sci U S A. 2000 May 9;97(10):5107-12. PMID:10792052

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