1dx5

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{{STRUCTURE_1dx5| PDB=1dx5 | SCENE= }}
{{STRUCTURE_1dx5| PDB=1dx5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX'''
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===CRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX===
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==Overview==
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The serine proteinase alpha-thrombin causes blood clotting through proteolytic cleavage of fibrinogen and protease-activated receptors and amplifies its own generation by activating the essential clotting factors V and VIII. Thrombomodulin, a transmembrane thrombin receptor with six contiguous epidermal growth factor-like domains (TME1-6), profoundly alters the substrate specificity of thrombin from pro- to anticoagulant by activating protein C. Activated protein C then deactivates the coagulation cascade by degrading activated factors V and VIII. The thrombin-thrombomodulin complex inhibits fibrinolysis by activating the procarboxypeptidase thrombin-activatable fibrinolysis inhibitor. Here we present the 2.3 A crystal structure of human alpha-thrombin bound to the smallest thrombomodulin fragment required for full protein-C co-factor activity, TME456. The Y-shaped thrombomodulin fragment binds to thrombin's anion-binding exosite-I, preventing binding of procoagulant substrates. Thrombomodulin binding does not seem to induce marked allosteric structural rearrangements at the thrombin active site. Rather, docking of a protein C model to thrombin-TME456 indicates that TME45 may bind substrates in such a manner that their zymogen-activation cleavage sites are presented optimally to the unaltered thrombin active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 10761923 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10761923}}
==About this Structure==
==About this Structure==
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[[Category: Egf-like domain]]
[[Category: Egf-like domain]]
[[Category: Serine proteinase]]
[[Category: Serine proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:23:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:44:57 2008''

Revision as of 20:44, 30 June 2008

Image:1dx5.png

Template:STRUCTURE 1dx5

CRYSTAL STRUCTURE OF THE THROMBIN-THROMBOMODULIN COMPLEX

Template:ABSTRACT PUBMED 10761923

About this Structure

1DX5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex., Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W, Nature. 2000 Mar 30;404(6777):518-25. PMID:10761923

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