1dxw

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[[Image:1dxw.gif|left|200px]]
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{{Seed}}
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[[Image:1dxw.png|left|200px]]
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{{STRUCTURE_1dxw| PDB=1dxw | SCENE= }}
{{STRUCTURE_1dxw| PDB=1dxw | SCENE= }}
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'''STRUCTURE OF HETERO COMPLEX OF NON STRUCTURAL PROTEIN (NS) OF HEPATITIS C VIRUS (HCV) AND SYNTHETIC PEPTIDIC COMPOUND'''
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===STRUCTURE OF HETERO COMPLEX OF NON STRUCTURAL PROTEIN (NS) OF HEPATITIS C VIRUS (HCV) AND SYNTHETIC PEPTIDIC COMPOUND===
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==Overview==
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Few structures of viral serine proteases, those encoded by the Sindbis and Semliki Forest viruses, hepatitis C virus (HCV) and cytomegalovirus, have been reported. In the life cycle of HCV a crucial role is played by a chymotrypsin-like serine protease encoded at the N-terminus of the viral NS3 protein, the solution structure of which we present here complexed with a covalently bound reversible inhibitor. Unexpectedly, the residue in the P2 position of the inhibitor induces an effective stabilization of the catalytic His-Asp hydrogen bond, by shielding that region of the protease from the solvent. This interaction appears crucial in the activation of the enzyme catalytic machinery and represents an unprecedented observation for this family of enzymes. Our data suggest that natural substrates of this serine protease could contribute to the enzyme activation by a similar induced-fit mechanism. The high degree of similarity at the His-Asp catalytic site region between HCV NS3 and other viral serine proteases suggests that this behaviour could be a more general feature for this category of viral enzymes.
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The line below this paragraph, {{ABSTRACT_PUBMED_10716920}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10716920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10716920}}
==About this Structure==
==About this Structure==
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1DXW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXW OCA].
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1DXW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DXW OCA].
==Reference==
==Reference==
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[[Category: Non structural protein]]
[[Category: Non structural protein]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:24:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:47:07 2008''

Revision as of 20:47, 30 June 2008

Image:1dxw.png

Template:STRUCTURE 1dxw

STRUCTURE OF HETERO COMPLEX OF NON STRUCTURAL PROTEIN (NS) OF HEPATITIS C VIRUS (HCV) AND SYNTHETIC PEPTIDIC COMPOUND

Template:ABSTRACT PUBMED 10716920

About this Structure

1DXW is a Single protein structure of sequence from Viruses. Full experimental information is available from OCA.

Reference

Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain., Barbato G, Cicero DO, Cordier F, Narjes F, Gerlach B, Sambucini S, Grzesiek S, Matassa VG, De Francesco R, Bazzo R, EMBO J. 2000 Mar 15;19(6):1195-206. PMID:10716920

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