1dy0

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[[Image:1dy0.gif|left|200px]]
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{{Seed}}
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[[Image:1dy0.png|left|200px]]
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{{STRUCTURE_1dy0| PDB=1dy0 | SCENE= }}
{{STRUCTURE_1dy0| PDB=1dy0 | SCENE= }}
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'''MURINE ENDOSTATIN, CRYSTAL FORM II'''
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===MURINE ENDOSTATIN, CRYSTAL FORM II===
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==Overview==
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Endostatin is a proteolytic fragment of collagen XVIII that potently inhibits angiogenesis and tumour growth. Human endostatin contains a zinc ion, bound near the N terminus, which was not observed in the original structure of mouse endostatin at pH 5. Controversial data exist on the role of this zinc ion in the anti-tumour activity. We report two new crystal structures of mouse endostatin at pH 8.5 with bound zinc. One crystal form shows a metal ion coordination similar to that in human endostatin (His132, His134, His142, Asp207), but the conformation of the N-terminal segment is different. In the other crystal form, Asp136 replaces His132 as a zinc ligand. Site-directed mutagenesis of zinc-binding residues demonstrates that both coordination geometries occur in solution. The large degree of structural heterogeneity of the zinc-binding site has implications for endostatin function. We conclude that zinc is likely to play a structural rather than a critical functional role in endostatin.
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The line below this paragraph, {{ABSTRACT_PUBMED_10704302}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10704302 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10704302}}
==About this Structure==
==About this Structure==
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[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
[[Category: Angiogenesis inhibitor]]
[[Category: Angiogenesis inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:25:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:47:20 2008''

Revision as of 20:47, 30 June 2008

Image:1dy0.png

Template:STRUCTURE 1dy0

MURINE ENDOSTATIN, CRYSTAL FORM II

Template:ABSTRACT PUBMED 10704302

About this Structure

1DY0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Variable zinc coordination in endostatin., Hohenester E, Sasaki T, Mann K, Timpl R, J Mol Biol. 2000 Mar 17;297(1):1-6. PMID:10704302

Page seeded by OCA on Mon Jun 30 23:47:20 2008

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