1dy8

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[[Image:1dy8.gif|left|200px]]
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{{Seed}}
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[[Image:1dy8.png|left|200px]]
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{{STRUCTURE_1dy8| PDB=1dy8 | SCENE= }}
{{STRUCTURE_1dy8| PDB=1dy8 | SCENE= }}
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'''INHIBITION OF THE HEPATITIS C VIRUS NS3/4A PROTEASE. THE CRYSTAL STRUCTURES OF TWO PROTEASE-INHIBITOR COMPLEXES (INHIBITOR II)'''
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===INHIBITION OF THE HEPATITIS C VIRUS NS3/4A PROTEASE. THE CRYSTAL STRUCTURES OF TWO PROTEASE-INHIBITOR COMPLEXES (INHIBITOR II)===
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==Overview==
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The hepatitis C virus NS3 protein contains a serine protease domain with a chymotrypsin-like fold, which is a target for development of therapeutics. We report the crystal structures of this domain complexed with NS4A cofactor and with two potent, reversible covalent inhibitors spanning the P1-P4 residues. Both inhibitors bind in an extended backbone conformation, forming an anti-parallel beta-sheet with one enzyme beta-strand. The P1 residue contributes most to the binding energy, whereas P2-P4 side chains are partially solvent exposed. The structures do not show notable rearrangements of the active site upon inhibitor binding. These results are significant for the development of antivirals.
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The line below this paragraph, {{ABSTRACT_PUBMED_10702283}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10702283 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10702283}}
==About this Structure==
==About this Structure==
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[[Category: Protease inhibition]]
[[Category: Protease inhibition]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:25:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:48:03 2008''

Revision as of 20:48, 30 June 2008

Image:1dy8.png

Template:STRUCTURE 1dy8

INHIBITION OF THE HEPATITIS C VIRUS NS3/4A PROTEASE. THE CRYSTAL STRUCTURES OF TWO PROTEASE-INHIBITOR COMPLEXES (INHIBITOR II)

Template:ABSTRACT PUBMED 10702283

About this Structure

1DY8 is a Single protein structure of sequence from Viruses. Full crystallographic information is available from OCA.

Reference

Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes., Di Marco S, Rizzi M, Volpari C, Walsh MA, Narjes F, Colarusso S, De Francesco R, Matassa VG, Sollazzo M, J Biol Chem. 2000 Mar 10;275(10):7152-7. PMID:10702283

Page seeded by OCA on Mon Jun 30 23:48:03 2008

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