1dz5

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[[Image:1dz5.gif|left|200px]]
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{{STRUCTURE_1dz5| PDB=1dz5 | SCENE= }}
{{STRUCTURE_1dz5| PDB=1dz5 | SCENE= }}
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'''THE NMR STRUCTURE OF THE 38KDA U1A PROTEIN-PIE RNA COMPLEX REVEALS THE BASIS OF COOPERATIVITY IN REGULATION OF POLYADENYLATION BY HUMAN U1A PROTEIN'''
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===THE NMR STRUCTURE OF THE 38KDA U1A PROTEIN-PIE RNA COMPLEX REVEALS THE BASIS OF COOPERATIVITY IN REGULATION OF POLYADENYLATION BY HUMAN U1A PROTEIN===
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==Overview==
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The status of the poly(A) tail at the 3'-end of mRNAs controls the expression of numerous genes in response to developmental and extracellular signals. Poly(A) tail regulation requires cooperative binding of two human U1A proteins to an RNA regulatory region called the polyadenylation inhibition element (PIE). When bound to PIE RNA, U1A proteins also bind to the enzyme responsible for formation of the mature 3'-end of most eukaryotic mRNAs, poly(A) polymerase (PAP). The NMR structure of the 38 kDa complex formed between two U1A molecules and PIE RNA shows that binding cooperativity depends on helix C located at the end of the RNA-binding domain and just adjacent to the PAP-interacting domain of U1A. Since helix C undergoes a conformational change upon RNA binding, the structure shows that binding cooperativity and interactions with PAP occur only when U1A is bound to its cognate RNA. This mechanism ensures that the activity of PAP enzyme, which is essential to the cell, is only down regulated when U1A is bound to the U1A mRNA.
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{{ABSTRACT_PUBMED_10742179}}
==About this Structure==
==About this Structure==
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1DZ5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZ5 OCA].
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1DZ5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZ5 OCA].
==Reference==
==Reference==
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[[Category: Rna protein interaction]]
[[Category: Rna protein interaction]]
[[Category: U1a protein]]
[[Category: U1a protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:27:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:50:41 2008''

Revision as of 20:50, 30 June 2008

Image:1dz5.png

Template:STRUCTURE 1dz5

THE NMR STRUCTURE OF THE 38KDA U1A PROTEIN-PIE RNA COMPLEX REVEALS THE BASIS OF COOPERATIVITY IN REGULATION OF POLYADENYLATION BY HUMAN U1A PROTEIN

Template:ABSTRACT PUBMED 10742179

About this Structure

1DZ5 is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein., Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G, Nat Struct Biol. 2000 Apr;7(4):329-35. PMID:10742179

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