1dzl

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[[Image:1dzl.gif|left|200px]]
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{{STRUCTURE_1dzl| PDB=1dzl | SCENE= }}
{{STRUCTURE_1dzl| PDB=1dzl | SCENE= }}
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'''L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16'''
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===L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16===
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==Overview==
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The papillomavirus major late protein, L1, forms the pentameric assembly unit of the viral shell. Recombinant HPV16 L1 pentamers assemble in vitro into capsid-like structures, and truncation of ten N-terminal residues leads to a homogeneous preparation of 12-pentamer, icosahedral particles. X-ray crystallographic analysis of these particles at 3.5 A resolution shows that L1 closely resembles VP1 from polyomaviruses. Surface loops contain the sites of sequence variation among HPV types and the locations of dominant neutralizing epitopes. The ease with which small virus-like particles may be obtained from L1 expressed in E. coli makes them attractive candidate components of a papillomavirus vaccine. Their crystal structure also provides a starting point for future vaccine design.
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(as it appears on PubMed at http://www.pubmed.gov), where 10882140 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10882140}}
==About this Structure==
==About this Structure==
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Icosahedral]]
[[Category: Icosahedral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:28:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:53:41 2008''

Revision as of 20:53, 30 June 2008

Image:1dzl.png

Template:STRUCTURE 1dzl

L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16

Template:ABSTRACT PUBMED 10882140

About this Structure

1DZL is a Single protein structure of sequence from Human papillomavirus type 16. Full crystallographic information is available from OCA.

Reference

Structure of small virus-like particles assembled from the L1 protein of human papillomavirus 16., Chen XS, Garcea RL, Goldberg I, Casini G, Harrison SC, Mol Cell. 2000 Mar;5(3):557-67. PMID:10882140

Page seeded by OCA on Mon Jun 30 23:53:41 2008

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