1e0o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1e0o.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1e0o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1e0o| PDB=1e0o | SCENE= }}
{{STRUCTURE_1e0o| PDB=1e0o | SCENE= }}
-
'''CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX'''
+
===CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX===
-
==Overview==
+
<!--
-
Fibroblast growth factors (FGFs) are a large family of structurally related proteins with a wide range of physiological and pathological activities. Signal transduction requires association of FGF with its receptor tyrosine kinase (FGFR) and heparan sulphate proteoglycan in a specific complex on the cell surface. Direct involvement of the heparan sulphate glycosaminoglycan polysaccharide in the molecular association between FGF and its receptor is essential for biological activity. Although crystal structures of binary complexes of FGF-heparin and FGF-FGFR have been described, the molecular architecture of the FGF signalling complex has not been elucidated. Here we report the crystal structure of the FGFR2 ectodomain in a dimeric form that is induced by simultaneous binding to FGF1 and a heparin decasaccharide. The complex is assembled around a central heparin molecule linking two FGF1 ligands into a dimer that bridges between two receptor chains. The asymmetric heparin binding involves contacts with both FGF1 molecules but only one receptor chain. The structure of the FGF1-FGFR2-heparin ternary complex provides a structural basis for the essential role of heparan sulphate in FGF signalling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11069186}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11069186 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11069186}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Ternary complex]]
[[Category: Ternary complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:47 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:56:51 2008''

Revision as of 20:56, 30 June 2008

Image:1e0o.png

Template:STRUCTURE 1e0o

CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX

Template:ABSTRACT PUBMED 11069186

About this Structure

1E0O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin., Pellegrini L, Burke DF, von Delft F, Mulloy B, Blundell TL, Nature. 2000 Oct 26;407(6807):1029-34. PMID:11069186

Page seeded by OCA on Mon Jun 30 23:56:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e0o"
Personal tools