1e0r

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{{Seed}}
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{{STRUCTURE_1e0r| PDB=1e0r | SCENE= }}
{{STRUCTURE_1e0r| PDB=1e0r | SCENE= }}
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'''BETA-APICAL DOMAIN OF THERMOSOME'''
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===BETA-APICAL DOMAIN OF THERMOSOME===
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==Overview==
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The crystal structure of the beta-apical domain of the thermosome, an archaeal group II chaperonin from Thermoplasma acidophilum, has been determined at 2.8 A resolution. The structure shows an invariant globular core from which a 25 A long protrusion emanates, composed of an elongated alpha-helix (H10) and a long extended stretch consisting of residues GluB245-ThrB253. A comparison with previous apical domain structures reveals a large segmental displacement of the protruding part of helix H10 via the hinge GluB276-ValB278. The region comprising residues GluB245-ThrB253 adopts an extended beta-like conformation rather than the alpha-helix seen in the alpha-apical domain. Consequently, it appears that the protrusions of the apical domains from group II chaperonins might assume a variety of context-dependent conformations during an open, substrate-accepting state of the chaperonin. Sequence variations in the protrusion regions that are found in the eukaryotic TRiC/CCT subunits may provide different structural propensities and hence serve different roles in substrate recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 10926489 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10926489}}
==About this Structure==
==About this Structure==
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[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermosome]]
[[Category: Thermosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:30:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:56:54 2008''

Revision as of 20:56, 30 June 2008

Image:1e0r.png

Template:STRUCTURE 1e0r

BETA-APICAL DOMAIN OF THERMOSOME

Template:ABSTRACT PUBMED 10926489

About this Structure

1E0R is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the beta-apical domain of the thermosome reveals structural plasticity in the protrusion region., Bosch G, Baumeister W, Essen LO, J Mol Biol. 2000 Aug 4;301(1):19-25. PMID:10926489

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