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1e21

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[[Image:1e21.gif|left|200px]]
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[[Image:1e21.png|left|200px]]
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{{STRUCTURE_1e21| PDB=1e21 | SCENE= }}
{{STRUCTURE_1e21| PDB=1e21 | SCENE= }}
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'''RIBONUCLEASE 1 DES1-7 CRYSTAL STRUCTURE AT 1.9A'''
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===RIBONUCLEASE 1 DES1-7 CRYSTAL STRUCTURE AT 1.9A===
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==Overview==
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Human pancreatic ribonuclease 1 (RNase 1) is considered to be the human counterpart of bovine pancreatic RNase A. Truncation of seven amino-acid residues from the amino-terminal sequence resulted in RNase 1 Delta N7, which has a reduced ribonucleolytic activity and a lower affinity for the human placental RNase inhibitor (PRI). This RNase 1 variant has been cloned, heterologously overexpressed, purified and crystallized. Its crystal structure has been determined and refined using data to 1.9 A resolution. The molecule displays the alpha + beta folding topology typical of members of the RNase A superfamily. The main distinct features found in RNase 1 Delta N7 are basically located in three loops affecting the fitting of the enzyme to the active site of subtilisin and the shape of the B2 subsite. These changes, taken with the lack of the catalytically active residue Lys7, may explain the reduced affinity of RNase 1 Delta N7 for PRI and the low ribonucleolytic activity of the protein when compared with the native enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_11264578}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11264578 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11264578}}
==About this Structure==
==About this Structure==
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[[Category: Rnase]]
[[Category: Rnase]]
[[Category: Rnase 1]]
[[Category: Rnase 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:01:03 2008''

Revision as of 21:01, 30 June 2008

Image:1e21.png

Template:STRUCTURE 1e21

RIBONUCLEASE 1 DES1-7 CRYSTAL STRUCTURE AT 1.9A

Template:ABSTRACT PUBMED 11264578

About this Structure

1E21 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution., Pous J, Mallorqui-Fernandez G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Ruth FX, Coll M, Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):498-505. PMID:11264578

Page seeded by OCA on Tue Jul 1 00:01:03 2008

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