1e5u

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{{STRUCTURE_1e5u| PDB=1e5u | SCENE= }}
{{STRUCTURE_1e5u| PDB=1e5u | SCENE= }}
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'''NMR REPRESENTATIVE STRUCTURE OF INTIMIN-190 (INT190) FROM ENTEROPATHOGENIC E. COLI'''
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===NMR REPRESENTATIVE STRUCTURE OF INTIMIN-190 (INT190) FROM ENTEROPATHOGENIC E. COLI===
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==Overview==
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Intimin is a bacterial adhesion molecule involved in intimate attachment of enteropathogenic and enterohaemorrhagic Escherichia coli to mammalian host cells. Intimin targets the translocated intimin receptor (Tir), which is exported by the bacteria and integrated into the host cell plasma membrane. In this study we localized the Tir-binding region of intimin to the C-terminal 190 amino acids (Int190). We have also determined the region's high-resolution solution structure, which comprises an immunoglobulin domain that is intimately coupled to a novel C-type lectin domain. This fragment, which is necessary and sufficient for Tir interaction, defines a new super domain in intimin that exhibits striking structural similarity to the integrin-binding domain of the Yersinia invasin and C-type lectin families. The extracellular portion of intimin comprises an articulated rod of immunoglobulin domains extending from the bacterium surface, conveying a highly accessible 'adhesive tip' to the target cell. The interpretation of NMR-titration and mutagenesis data has enabled us to identify, for the first time, the binding site for Tir, which is located at the extremity of the Int190 moiety.
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{{ABSTRACT_PUBMED_10835344}}
==About this Structure==
==About this Structure==
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1E5U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e1b 1e1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5U OCA].
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1E5U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1e1b 1e1b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E5U OCA].
==Reference==
==Reference==
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[[Category: Nmr spectroscopy]]
[[Category: Nmr spectroscopy]]
[[Category: Outer membrane protein]]
[[Category: Outer membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:42:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:11:54 2008''

Revision as of 21:11, 30 June 2008

Image:1e5u.png

Template:STRUCTURE 1e5u

NMR REPRESENTATIVE STRUCTURE OF INTIMIN-190 (INT190) FROM ENTEROPATHOGENIC E. COLI

Template:ABSTRACT PUBMED 10835344

About this Structure

1E5U is a Single protein structure of sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1e1b. Full experimental information is available from OCA.

Reference

Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli., Batchelor M, Prasannan S, Daniell S, Reece S, Connerton I, Bloomberg G, Dougan G, Frankel G, Matthews S, EMBO J. 2000 Jun 1;19(11):2452-64. PMID:10835344

Page seeded by OCA on Tue Jul 1 00:11:54 2008

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