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1e7k

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[[Image:1e7k.gif|left|200px]]
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{{STRUCTURE_1e7k| PDB=1e7k | SCENE= }}
{{STRUCTURE_1e7k| PDB=1e7k | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT'''
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===CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT===
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==Overview==
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We have determined the crystal structure of a spliceosomal RNP complex comprising the 15.5kD protein of the human U4/U6.U5 tri-snRNP and the 5' stem-loop of U4 snRNA. The protein interacts almost exclusively with a purine-rich (5+2) internal loop within the 5' stem-loop, giving an unusual RNA fold characterized by two tandem sheared G-A base pairs, a high degree of purine stacking, and the accommodation of a single RNA base, rotated out of the RNA chain, in a pocket of the protein. Apart from yielding the structure of an important entity in the pre-mRNA splicing apparatus, this work also implies a model for the complex of the 15.5kD protein with box C/D snoRNAs. It additionally suggests a general recognition principle in a novel family of RNA binding proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_11163207}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11163207 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11163207}}
==About this Structure==
==About this Structure==
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[[Category: Splicing]]
[[Category: Splicing]]
[[Category: U4 snrna]]
[[Category: U4 snrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:45:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:16:59 2008''

Revision as of 21:17, 30 June 2008

Image:1e7k.png

Template:STRUCTURE 1e7k

CRYSTAL STRUCTURE OF THE SPLICEOSOMAL 15.5KD PROTEIN BOUND TO A U4 SNRNA FRAGMENT

Template:ABSTRACT PUBMED 11163207

About this Structure

1E7K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment., Vidovic I, Nottrott S, Hartmuth K, Luhrmann R, Ficner R, Mol Cell. 2000 Dec;6(6):1331-42. PMID:11163207

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