1e8b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1e8b.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1e8b.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1e8b| PDB=1e8b | SCENE= }}
{{STRUCTURE_1e8b| PDB=1e8b | SCENE= }}
-
'''SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN'''
+
===SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN===
-
==Overview==
+
<!--
-
The solution structure of the (6)F1(1)F2(2)F2 fragment from the gelatin-binding region of fibronectin has been determined (Protein Data Bank entry codes 1e88 and 1e8b). The structure reveals an extensive hydrophobic interface between the non-contiguous (6)F1 and (2)F2 modules. The buried surface area between (6)F1 and (2)F2 ( approximately 870 A(2)) is the largest intermodule interface seen in fibronectin to date. The dissection of (6)F1(1)F2(2)F2 into the (6)F1(1)F2 pair and (2)F2 results in near-complete loss of gelatin-binding activity. The hairpin topology of (6)F1(1)F2(2)F2 may facilitate intramolecular contact between the matrix assembly regions flanking the gelatin-binding domain. This is the first high-resolution study to reveal a compact, globular arrangement of modules in fibronectin. This arrangement is not consistent with the view that fibronectin is simply a linear 'string of beads'.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11285216}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11285216 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11285216}}
==About this Structure==
==About this Structure==
-
1E8B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8B OCA].
+
1E8B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8B OCA].
==Reference==
==Reference==
Line 28: Line 32:
[[Category: Staunton, D.]]
[[Category: Staunton, D.]]
[[Category: Extracellular matrix glycoprotein]]
[[Category: Extracellular matrix glycoprotein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:47:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:18:36 2008''

Revision as of 21:18, 30 June 2008

Image:1e8b.png

Template:STRUCTURE 1e8b

SOLUTION STRUCTURE OF 6F11F22F2, A COMPACT THREE-MODULE FRAGMENT OF THE GELATIN-BINDING DOMAIN OF HUMAN FIBRONECTIN

Template:ABSTRACT PUBMED 11285216

About this Structure

1E8B is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding., Pickford AR, Smith SP, Staunton D, Boyd J, Campbell ID, EMBO J. 2001 Apr 2;20(7):1519-29. PMID:11285216

Page seeded by OCA on Tue Jul 1 00:18:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e8b"
Personal tools