1e8o

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[[Image:1e8o.jpg|left|200px]]
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{{Seed}}
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[[Image:1e8o.png|left|200px]]
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{{STRUCTURE_1e8o| PDB=1e8o | SCENE= }}
{{STRUCTURE_1e8o| PDB=1e8o | SCENE= }}
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'''CORE OF THE ALU DOMAIN OF THE MAMMALIAN SRP'''
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===CORE OF THE ALU DOMAIN OF THE MAMMALIAN SRP===
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==Overview==
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The Alu domain of the mammalian signal recognition particle (SRP) comprises the heterodimer of proteins SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. It retards the ribosomal elongation of signal-peptide-containing proteins before their engagement with the translocation machinery in the endoplasmic reticulum. Here we report two crystal structures of the heterodimer SRP9/14 bound either to the 5' domain or to a construct containing both 5' and 3' domains. We present a model of the complete Alu domain that is consistent with extensive biochemical data. SRP9/14 binds strongly to the conserved core of the 5' domain, which forms a U-turn connecting two helical stacks. Reversible docking of the more weakly bound 3' domain might be functionally important in the mechanism of translational regulation. The Alu domain structure is probably conserved in other cytoplasmic ribonucleoprotein particles and retroposition intermediates containing SRP9/14-bound RNAs transcribed from Alu repeats or related elements in genomic DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_11089964}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11089964 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11089964}}
==About this Structure==
==About this Structure==
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[[Category: Protein recognition of an rna u-turn]]
[[Category: Protein recognition of an rna u-turn]]
[[Category: Translational control]]
[[Category: Translational control]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:47:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:19:46 2008''

Revision as of 21:19, 30 June 2008

Image:1e8o.png

Template:STRUCTURE 1e8o

CORE OF THE ALU DOMAIN OF THE MAMMALIAN SRP

Template:ABSTRACT PUBMED 11089964

About this Structure

1E8O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and assembly of the Alu domain of the mammalian signal recognition particle., Weichenrieder O, Wild K, Strub K, Cusack S, Nature. 2000 Nov 9;408(6809):167-73. PMID:11089964

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