1eay

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[[Image:1eay.gif|left|200px]]
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{{Seed}}
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[[Image:1eay.png|left|200px]]
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{{STRUCTURE_1eay| PDB=1eay | SCENE= }}
{{STRUCTURE_1eay| PDB=1eay | SCENE= }}
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'''CHEY-BINDING (P2) DOMAIN OF CHEA IN COMPLEX WITH CHEY FROM ESCHERICHIA COLI'''
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===CHEY-BINDING (P2) DOMAIN OF CHEA IN COMPLEX WITH CHEY FROM ESCHERICHIA COLI===
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==Overview==
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The crystal structure at 2.0-A resolution of the complex of the Escherichia coli chemotaxis response regulator CheY and the phosphoacceptor-binding domain (P2) of the kinase CheA is presented. The binding interface involves the fourth and fifth helices and fifth beta-strand of CheY and both helices of P2. Surprisingly, the two heterodimers in the asymmetric unit have two different binding modes involving the same interface, suggesting some flexibility in the binding regions. Significant conformational changes have occurred in CheY compared with previously determined unbound structures. The active site of CheY is exposed by the binding of the kinase domain, possibly to enhance phosphotransfer from CheA to CheY. The conformational changes upon complex formation as well as the observation that there are two different binding modes suggest that the plasticity of CheY is an essential feature of response regulator function.
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The line below this paragraph, {{ABSTRACT_PUBMED_9636149}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9636149 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9636149}}
==About this Structure==
==About this Structure==
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[[Category: Response regulator]]
[[Category: Response regulator]]
[[Category: Signal transduction complex]]
[[Category: Signal transduction complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:53:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:25:51 2008''

Revision as of 21:25, 30 June 2008

Image:1eay.png

Template:STRUCTURE 1eay

CHEY-BINDING (P2) DOMAIN OF CHEA IN COMPLEX WITH CHEY FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 9636149

About this Structure

1EAY is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Two binding modes reveal flexibility in kinase/response regulator interactions in the bacterial chemotaxis pathway., McEvoy MM, Hausrath AC, Randolph GB, Remington SJ, Dahlquist FW, Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7333-8. PMID:9636149

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