1ebo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ebo.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ebo.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ebo| PDB=1ebo | SCENE= }}
{{STRUCTURE_1ebo| PDB=1ebo | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE EBOLA VIRUS MEMBRANE-FUSION SUBUNIT, GP2, FROM THE ENVELOPE GLYCOPROTEIN ECTODOMAIN'''
+
===CRYSTAL STRUCTURE OF THE EBOLA VIRUS MEMBRANE-FUSION SUBUNIT, GP2, FROM THE ENVELOPE GLYCOPROTEIN ECTODOMAIN===
-
==Overview==
+
<!--
-
We have determined the structure of GP2 from the Ebola virus membrane fusion glycoprotein by X-ray crystallography. The molecule contains a central triple-stranded coiled coil followed by a disulfide-bonded loop homologous to an immunosuppressive sequence in retroviral glycoproteins, which reverses the chain direction and connects to an alpha helix packed antiparallel to the core helices. The structure suggests that fusion peptides near the N termini form disulfide-bonded loops at one end of the molecule and that the C-terminal membrane anchors are at the same end. In this conformation, GP2 could both bridge two membranes and facilitate their apposition to initiate membrane fusion. We also find a heptad irregularity like that in low-pH-induced influenza HA2 and a solvent ion trapped in a coiled coil like that in retroviral TMs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9844633}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9844633 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9844633}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Membrane fusion subunit]]
[[Category: Membrane fusion subunit]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:54:34 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:27:43 2008''

Revision as of 21:27, 30 June 2008

Image:1ebo.png

Template:STRUCTURE 1ebo

CRYSTAL STRUCTURE OF THE EBOLA VIRUS MEMBRANE-FUSION SUBUNIT, GP2, FROM THE ENVELOPE GLYCOPROTEIN ECTODOMAIN

Template:ABSTRACT PUBMED 9844633

About this Structure

1EBO is a Single protein structure of sequence from Ebola virus sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain., Weissenhorn W, Carfi A, Lee KH, Skehel JJ, Wiley DC, Mol Cell. 1998 Nov;2(5):605-16. PMID:9844633

Page seeded by OCA on Tue Jul 1 00:27:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ebo"
Personal tools