1ebp

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{{STRUCTURE_1ebp| PDB=1ebp | SCENE= }}
{{STRUCTURE_1ebp| PDB=1ebp | SCENE= }}
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'''COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]'''
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===COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]===
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==Overview==
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The functional mimicry of a protein by an unrelated small molecule has been a formidable challenge. Now, however, the biological activity of a 166-residue hematopoietic growth hormone, erythropoietin (EPO), with its class 1 cytokine receptor has been mimicked by a 20-residue cyclic peptide unrelated in sequence to the natural ligand. The crystal structure at 2.8 A resolution of a complex of this agonist peptide with the extracellular domain of EPO receptor reveals that a peptide dimer induces an almost perfect twofold dimerization of the receptor. The dimer assembly differs from that of the human growth hormone (hGH) receptor complex and suggests that more than one mode of dimerization may be able to induce signal transduction and cell proliferation. The EPO receptor binding site, defined by peptide interaction, corresponds to the smaller functional epitope identified for hGH receptor. Similarly, the EPO mimetic peptide ligand can be considered as a minimal hormone, and suggests the design of nonpeptidic small molecule mimetics for EPO and other cytokines may indeed be achievable.
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(as it appears on PubMed at http://www.pubmed.gov), where 8662530 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8662530}}
==About this Structure==
==About this Structure==
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[[Category: Protein minimization]]
[[Category: Protein minimization]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:54:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:27:45 2008''

Revision as of 21:27, 30 June 2008

Image:1ebp.png

Template:STRUCTURE 1ebp

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]

Template:ABSTRACT PUBMED 8662530

About this Structure

1EBP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A., Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, Wilson IA, Science. 1996 Jul 26;273(5274):464-71. PMID:8662530

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