1ebt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ebt.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ebt.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ebt| PDB=1ebt | SCENE= }}
{{STRUCTURE_1ebt| PDB=1ebt | SCENE= }}
-
'''HEMOGLOBIN I FROM THE CLAM LUCINA PECTINATA BOUND WITH CYANIDE'''
+
===HEMOGLOBIN I FROM THE CLAM LUCINA PECTINATA BOUND WITH CYANIDE===
-
==Overview==
+
<!--
-
The x-ray crystal structures of the cyanide derivative of Lucina pectinata monomeric hemoglobin I (L. pectinata HbI) and sperm whale (Physeter catodon) myoglobin (Mb), generally taken as reference models for monomeric hemoproteins carrying hydrogen sulfide and oxygen, respectively, have been determined at 1.9 A (R-factor = 0. 184), and 1.8 A (R-factor = 0.181) resolution, respectively, at room temperature (lambda = 1.542 A). Moreover, the x-ray crystal structure of the L. pectinata HbI:cyanide derivative has been studied at 1.4-A resolution (R-factor = 0.118) and 100 K (on a synchrotron source lambda = 0.998 A). At room temperature, the cyanide ligand is roughly parallel to the heme plane of L. pectinata HbI, being located approximately 2.5 A from the iron atom. On the other hand, the crystal structure of the L. pectinata HbI:cyanide derivative at 100 K shows that the diatomic ligand is coordinated to the iron atom in an orientation almost perpendicular to the heme (the Fe-C distance being 1.95 A), adopting a coordination geometry strictly reminescent of that observed in sperm whale Mb, at room temperature. The unusual cyanide distal site orientation observed in L. pectinata HbI, at room temperature, may reflect reduction of the heme Fe(III) atom induced by free radical species during x-ray data collection using Cu Kalpha radiation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10423453}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10423453 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10423453}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Oxygen carrier]]
[[Category: Oxygen carrier]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:55:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:28:00 2008''

Revision as of 21:28, 30 June 2008

Image:1ebt.png

Template:STRUCTURE 1ebt

HEMOGLOBIN I FROM THE CLAM LUCINA PECTINATA BOUND WITH CYANIDE

Template:ABSTRACT PUBMED 10423453

About this Structure

1EBT is a Single protein structure of sequence from Lucina pectinata. Full crystallographic information is available from OCA.

Reference

Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study., Bolognesi M, Rosano C, Losso R, Borassi A, Rizzi M, Wittenberg JB, Boffi A, Ascenzi P, Biophys J. 1999 Aug;77(2):1093-9. PMID:10423453

Page seeded by OCA on Tue Jul 1 00:28:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ebt"
Personal tools