1ec6

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{{STRUCTURE_1ec6| PDB=1ec6 | SCENE= }}
{{STRUCTURE_1ec6| PDB=1ec6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN BOUND TO 20-MER RNA HAIRPIN'''
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===CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN BOUND TO 20-MER RNA HAIRPIN===
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==Overview==
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The structure of a Nova protein K homology (KH) domain recognizing single-stranded RNA has been determined at 2.4 A resolution. Mammalian Nova antigens (1 and 2) constitute an important family of regulators of RNA metabolism in neurons, first identified using sera from cancer patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA). The structure of the third KH domain (KH3) of Nova-2 bound to a stem loop RNA resembles a molecular vise, with 5'-Ura-Cyt-Ade-Cyt-3' pinioned between an invariant Gly-X-X-Gly motif and the variable loop. Tetranucleotide recognition is supported by an aliphatic alpha helix/beta sheet RNA-binding platform, which mimics 5'-Ura-Gua-3' by making Watson-Crick-like hydrogen bonds with 5'-Cyt-Ade-3'. Sequence conservation suggests that fragile X mental retardation results from perturbation of RNA binding by the FMR1 protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 10676814 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10676814}}
==About this Structure==
==About this Structure==
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[[Category: Protein/rna structure]]
[[Category: Protein/rna structure]]
[[Category: Rna-binding motif]]
[[Category: Rna-binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:55:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:28:59 2008''

Revision as of 21:28, 30 June 2008

Image:1ec6.png

Template:STRUCTURE 1ec6

CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN BOUND TO 20-MER RNA HAIRPIN

Template:ABSTRACT PUBMED 10676814

About this Structure

1EC6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome., Lewis HA, Musunuru K, Jensen KB, Edo C, Chen H, Darnell RB, Burley SK, Cell. 2000 Feb 4;100(3):323-32. PMID:10676814

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