1ed1

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{{Seed}}
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{{STRUCTURE_1ed1| PDB=1ed1 | SCENE= }}
{{STRUCTURE_1ed1| PDB=1ed1 | SCENE= }}
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'''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.'''
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===CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.===
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==Overview==
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Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.
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The line below this paragraph, {{ABSTRACT_PUBMED_7501025}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7501025 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7501025}}
==About this Structure==
==About this Structure==
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: Trimeric association]]
[[Category: Trimeric association]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:57:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:30:49 2008''

Revision as of 21:30, 30 June 2008

Image:1ed1.png

Template:STRUCTURE 1ed1

CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.

Template:ABSTRACT PUBMED 7501025

About this Structure

1ED1 is a Single protein structure of sequence from Simian immunodeficiency virus - mac. Full crystallographic information is available from OCA.

Reference

Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:7501025

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