1ed3

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[[Image:1ed3.gif|left|200px]]
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{{Seed}}
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[[Image:1ed3.png|left|200px]]
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{{STRUCTURE_1ed3| PDB=1ed3 | SCENE= }}
{{STRUCTURE_1ed3| PDB=1ed3 | SCENE= }}
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'''CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.'''
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===CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.===
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==Overview==
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The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen. The antigenic structure of MTF-E was unpredictable due to its extraordinary length and two arginines that could serve as potential anchor residues. The crystal structure of RT1-Aa-MTF-E at 2.55 A shows that both peptide termini are anchored, as in other class I molecules, but the central residues in two independent pMHC complexes adopt completely different bulged conformations based on local environment. The MTF-E epitope is fully exposed within the putative T cell receptor (TCR) footprint. The flexibility demonstrated by the MTF-E structures illustrates how different TCRs may be raised against chemically identical, but structurally dissimilar, pMHC complexes.
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The line below this paragraph, {{ABSTRACT_PUBMED_11163232}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11163232 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11163232}}
==About this Structure==
==About this Structure==
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[[Category: Rat minor histocompatibility complex]]
[[Category: Rat minor histocompatibility complex]]
[[Category: T cell receptor ligand]]
[[Category: T cell receptor ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:57:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:30:52 2008''

Revision as of 21:30, 30 June 2008

Image:1ed3.png

Template:STRUCTURE 1ed3

CRYSTAL STRUCTURE OF RAT MINOR HISTOCOMPATIBILITY ANTIGEN COMPLEX RT1-AA/MTF-E.

Template:ABSTRACT PUBMED 11163232

About this Structure

1ED3 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa., Speir JA, Stevens J, Joly E, Butcher GW, Wilson IA, Immunity. 2001 Jan;14(1):81-92. PMID:11163232

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