1edm

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{{STRUCTURE_1edm| PDB=1edm | SCENE= }}
{{STRUCTURE_1edm| PDB=1edm | SCENE= }}
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'''EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX'''
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===EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX===
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==Overview==
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Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. We have determined, at high resolution (1.5 A), the crystal structure of such a domain, from human clotting factor IX, as a complex with Ca2+. The Ca2+ ligands form a classic pentagonal bipyramid with six ligands contributed by one polypeptide chain and the seventh supplied by a neighboring EGF-like domain. The crystal structure identifies the role of Ca2+ in maintaining the conformation of the N-terminal region of the domain, but more importantly demonstrates that Ca2+ can directly mediate protein-protein contacts. The observed crystal packing of the domains provides a plausible model for the association of multiple tandemly linked EGF-like domains in proteins such as fibrillin-1, Notch, and protein S. This model is consistent with the known functional data and suggests a general biological role for these domains.
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{{ABSTRACT_PUBMED_7606779}}
==About this Structure==
==About this Structure==
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[[Category: Human factor ix]]
[[Category: Human factor ix]]
[[Category: Structure and function]]
[[Category: Structure and function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:58:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:32:10 2008''

Revision as of 21:32, 30 June 2008

Image:1edm.png

Template:STRUCTURE 1edm

EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX

Template:ABSTRACT PUBMED 7606779

About this Structure

1EDM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions., Rao Z, Handford P, Mayhew M, Knott V, Brownlee GG, Stuart D, Cell. 1995 Jul 14;82(1):131-41. PMID:7606779

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