1ega

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{{STRUCTURE_1ega| PDB=1ega | SCENE= }}
{{STRUCTURE_1ega| PDB=1ega | SCENE= }}
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'''CRYSTAL STRUCTURE OF A WIDELY CONSERVED GTPASE ERA'''
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===CRYSTAL STRUCTURE OF A WIDELY CONSERVED GTPASE ERA===
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==Overview==
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ERA forms a unique family of GTPase. It is widely conserved and essential in bacteria. ERA functions in cell cycle control by coupling cell division with growth rate. ERA homologues also are found in eukaryotes. Here we report the crystal structure of ERA from Escherichia coli. The structure has been determined at 2.4-A resolution. It reveals a two-domain arrangement of the molecule: an N-terminal domain that resembles p21 Ras and a C-terminal domain that is unique. Structure-based topological search of the C domain fails to reveal any meaningful match, although sequence analysis suggests that it contains a KH domain. KH domains are RNA binding motifs that usually occur in tandem repeats and exhibit low sequence similarity except for the well-conserved segment VIGxxGxxIK. We have identified a betaalphaalphabeta fold that contains the VIGxxGxxIK sequence and is shared by the C domain of ERA and the KH domain. We propose that this betaalphaalphabeta fold is the RNA binding motif, the minimum structural requirement for RNA binding. ERA dimerizes in crystal. The dimer formation involves a significantly distorted switch II region, which may shed light on how ERA protein regulates downstream events.
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{{ABSTRACT_PUBMED_10411886}}
==About this Structure==
==About this Structure==
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[[Category: Ras-like]]
[[Category: Ras-like]]
[[Category: Rna-binding]]
[[Category: Rna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:03:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:39:10 2008''

Revision as of 21:39, 30 June 2008

Image:1ega.png

Template:STRUCTURE 1ega

CRYSTAL STRUCTURE OF A WIDELY CONSERVED GTPASE ERA

Template:ABSTRACT PUBMED 10411886

About this Structure

1EGA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif., Chen X, Court DL, Ji X, Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8396-401. PMID:10411886

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