1ehx

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{{STRUCTURE_1ehx| PDB=1ehx | SCENE= }}
{{STRUCTURE_1ehx| PDB=1ehx | SCENE= }}
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'''NMR SOLUTION STRUCTURE OF THE LAST UNKNOWN MODULE OF THE CELLULOSOMAL SCAFFOLDIN PROTEIN CIPC OF CLOSTRIDUM CELLULOLYTICUM'''
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===NMR SOLUTION STRUCTURE OF THE LAST UNKNOWN MODULE OF THE CELLULOSOMAL SCAFFOLDIN PROTEIN CIPC OF CLOSTRIDUM CELLULOLYTICUM===
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==Overview==
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Multidimensional, homo- and heteronuclear magnetic resonance spectroscopy combined with dynamical annealing has been used to determine the structure of a 94 residue module (X2 1) of the scaffolding protein CipC from the anaerobic bacterium Clostridium cellulolyticum. An experimental data set comprising 1647 nuclear Overhauser effect-derived restraints, 105 hydrogen bond restraints and 66 phi torsion angle restraints was used to calculate 20 converging final solutions. The calculated structures have an average rmsd about the mean structure of 0.55(+/-0.11) A for backbone atoms and 1.40(+/-0.11) A for all heavy atoms when fitted over the secondary structural elements. The X2 1 module has an immunoglobulin-like fold with two beta-sheets packed against each other. One sheet contains three strands, the second contains four strands. An additional strand is intercalated between the beta-sandwich, as well as two turns of a 3(.10) helix. X2 1 has a surprising conformational stability and may act as a conformational linker and solubility enhancer within the scaffolding protein. The fold of X2 1 is very similar to that of telokin, titin Ig domain, hemolin D2 domain, twitchin immunoglobulin domain and the first four domains of the IgSF portion of transmembrane cell adhesion molecule. As a consequence, the X2 1 module is the first prokaryotic member assigned to the I set of the immunoglobulin superfamily even though no sequence similarity with any member of this superfamily could be detected.
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(as it appears on PubMed at http://www.pubmed.gov), where 11080456 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11080456}}
==About this Structure==
==About this Structure==
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1EHX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_cellulolyticum Clostridium cellulolyticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHX OCA].
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1EHX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_cellulolyticum Clostridium cellulolyticum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EHX OCA].
==Reference==
==Reference==
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[[Category: 3 10 helix]]
[[Category: 3 10 helix]]
[[Category: Beta-beta-barrel]]
[[Category: Beta-beta-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:07:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:43:11 2008''

Revision as of 21:43, 30 June 2008

Image:1ehx.png

Template:STRUCTURE 1ehx

NMR SOLUTION STRUCTURE OF THE LAST UNKNOWN MODULE OF THE CELLULOSOMAL SCAFFOLDIN PROTEIN CIPC OF CLOSTRIDUM CELLULOLYTICUM

Template:ABSTRACT PUBMED 11080456

About this Structure

1EHX is a Single protein structure of sequence from Clostridium cellulolyticum. Full experimental information is available from OCA.

Reference

Solution structure of the module X2 1 of unknown function of the cellulosomal scaffolding protein CipC of Clostridium cellulolyticum., Mosbah A, Belaich A, Bornet O, Belaich JP, Henrissat B, Darbon H, J Mol Biol. 2000 Nov 24;304(2):201-17. PMID:11080456

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