1eiz

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{{STRUCTURE_1eiz| PDB=1eiz | SCENE= }}
{{STRUCTURE_1eiz| PDB=1eiz | SCENE= }}
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'''FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE'''
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===FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE===
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==Overview==
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Structural, biochemical, and genetic techniques were applied to investigate the function of FtsJ, a recently identified heat shock protein. FtsJ is well conserved, from bacteria to humans. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. The molecular surface of FtsJ exposes a putative nucleic acid binding groove composed of highly conserved, positively charged residues. Substrate analysis showed that FtsJ methylates 23S rRNA within 50S ribosomal subunits in vitro and in vivo. Null mutations in ftsJ show a dramatically altered ribosome profile, a severe growth disadvantage, and a temperature-sensitive phenotype. Our results reveal an unexpected link between the heat shock response and RNA metabolism.
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(as it appears on PubMed at http://www.pubmed.gov), where 10983982 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10983982}}
==About this Structure==
==About this Structure==
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[[Category: Heat shock protein]]
[[Category: Heat shock protein]]
[[Category: Methyltransferase]]
[[Category: Methyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:09:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:49:03 2008''

Revision as of 21:49, 30 June 2008

Image:1eiz.png

Template:STRUCTURE 1eiz

FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE

Template:ABSTRACT PUBMED 10983982

About this Structure

1EIZ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

RNA methylation under heat shock control., Bugl H, Fauman EB, Staker BL, Zheng F, Kushner SR, Saper MA, Bardwell JC, Jakob U, Mol Cell. 2000 Aug;6(2):349-60. PMID:10983982

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