1ej5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ej5.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ej5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ej5| PDB=1ej5 | SCENE= }}
{{STRUCTURE_1ej5| PDB=1ej5 | SCENE= }}
-
'''SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP'''
+
===SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP===
-
==Overview==
+
<!--
-
The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of the GTPase-binding domain of WASP, which can be induced by the C-terminal region or by organic co-solvents. In the autoinhibited complex, intramolecular interactions with the GTPase-binding domain occlude residues of the C terminus that regulate the Arp2/3 actin-nucleating complex. Binding of Cdc42 to the GTPase-binding domain causes a dramatic conformational change, resulting in disruption of the hydrophobic core and release of the C terminus, enabling its interaction with the actin regulatory machinery. These data show that 'intrinsically unstructured' peptides such as the GTPase-binding domain of WASP can be induced into distinct structural and functional states depending on context.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10724160}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10724160 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10724160}}
==About this Structure==
==About this Structure==
-
1EJ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ5 OCA].
+
1EJ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ5 OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Alpha helix]]
[[Category: Alpha helix]]
[[Category: Beta-hairpin turn]]
[[Category: Beta-hairpin turn]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:09:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:49:33 2008''

Revision as of 21:49, 30 June 2008

Image:1ej5.png

Template:STRUCTURE 1ej5

SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP

Template:ABSTRACT PUBMED 10724160

About this Structure

1EJ5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein., Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK, Nature. 2000 Mar 9;404(6774):151-8. PMID:10724160

Page seeded by OCA on Tue Jul 1 00:49:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ej5"
Personal tools