1ejl

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{{STRUCTURE_1ejl| PDB=1ejl | SCENE= }}
{{STRUCTURE_1ejl| PDB=1ejl | SCENE= }}
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'''MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX'''
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===MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX===
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==Overview==
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Importin-alpha is the nuclear import receptor that recognizes cargo proteins which contain classical monopartite and bipartite nuclear localization sequences (NLSs), and facilitates their transport into the nucleus. To determine the structural basis of the recognition of the two classes of NLSs by mammalian importin-alpha, we co-crystallized an N-terminally truncated mouse receptor protein with peptides corresponding to the monopartite NLS from the simian virus 40 (SV40) large T-antigen, and the bipartite NLS from nucleoplasmin. We show that the monopartite SV40 large T-antigen NLS binds to two binding sites on the receptor, similar to what was observed in yeast importin-alpha. The nucleoplasmin NLS-importin-alpha complex shows, for the first time, the mode of binding of bipartite NLSs to the receptor. The two basic clusters in the NLS occupy the two binding sites used by the monopartite NLS, while the sequence linking the two basic clusters is poorly ordered, consistent with its tolerance to mutations. The structures explain the structural basis for binding of diverse NLSs to the sole receptor protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 10764582 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10764582}}
==About this Structure==
==About this Structure==
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[[Category: Teh, T.]]
[[Category: Teh, T.]]
[[Category: Importin alpha/karyopherin alpha]]
[[Category: Importin alpha/karyopherin alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:10:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:51:06 2008''

Revision as of 21:51, 30 June 2008

Image:1ejl.png

Template:STRUCTURE 1ejl

MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX

Template:ABSTRACT PUBMED 10764582

About this Structure

1EJL is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha., Fontes MR, Teh T, Kobe B, J Mol Biol. 2000 Apr 14;297(5):1183-94. PMID:10764582

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