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1ek0

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{{STRUCTURE_1ek0| PDB=1ek0 | SCENE= }}
{{STRUCTURE_1ek0| PDB=1ek0 | SCENE= }}
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'''GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION'''
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===GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION===
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==Overview==
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Ypt/Rab proteins are membrane-associated small GTP-binding proteins which play a central role in the coordination, activation and regulation of vesicle-mediated transport in eukaryotic cells. We present the 1.5 A high-resolution crystal structure of Ypt51 in its active, GppNHp-bound conformation. Ypt51 is an important regulator involved in the endocytic membrane traffic of Saccharomyces cerevisiae. The structure reveals small but significant structural differences compared with H-Ras p21. The effector loop and the catalytic loop are well defined and stabilized by extensive hydrophobic interactions. The switch I and switch II regions form a well-defined epitope for hypothetical effector protein binding. Sequence comparisons between the different isoforms Ypt51, Ypt52 and Ypt53 provide the first insights into determinants for specific effector binding and for fine-tuning of the intrinsic GTP-hydrolysis rate.
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{{ABSTRACT_PUBMED_10756108}}
==About this Structure==
==About this Structure==
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[[Category: Vesicular traffic]]
[[Category: Vesicular traffic]]
[[Category: Ypt/rab protein]]
[[Category: Ypt/rab protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:11:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:52:16 2008''

Revision as of 21:52, 30 June 2008

Image:1ek0.png

Template:STRUCTURE 1ek0

GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION

Template:ABSTRACT PUBMED 10756108

About this Structure

1EK0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis., Esters H, Alexandrov K, Constantinescu AT, Goody RS, Scheidig AJ, J Mol Biol. 2000 Apr 21;298(1):111-21. PMID:10756108

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