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1ekj

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{{STRUCTURE_1ekj| PDB=1ekj | SCENE= }}
{{STRUCTURE_1ekj| PDB=1ekj | SCENE= }}
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'''THE X-RAY CRYSTALLOGRAPHIC STRUCTURE OF BETA CARBONIC ANHYDRASE FROM THE C3 DICOT PISUM SATIVUM'''
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===THE X-RAY CRYSTALLOGRAPHIC STRUCTURE OF BETA CARBONIC ANHYDRASE FROM THE C3 DICOT PISUM SATIVUM===
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==Overview==
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We have determined the structure of the beta-carbonic anhydrase from the dicotyledonous plant Pisum sativum at 1.93 A resolution, using a combination of multiple anomalous scattering off the active site zinc ion and non-crystallographic symmetry averaging. The mol- ecule assembles as an octamer with a novel dimer of dimers of dimers arrangement. Two distinct patterns of conservation of active site residues are observed, implying two potentially mechanistically distinct classes of beta-carbonic anhydrases. The active site is located at the interface between two monomers, with Cys160, His220 and Cys223 binding the catalytic zinc ion and residues Asp162 (oriented by Arg164), Gly224, Gln151, Val184, Phe179 and Tyr205 interacting with the substrate analogue, acetic acid. The substrate binding groups have a one to one correspondence with the functional groups in the alpha-carbonic anhydrase active site, with the corresponding residues being closely superimposable by a mirror plane. Therefore, despite differing folds, alpha- and beta-carbonic anhydrase have converged upon a very similar active site design and are likely to share a common mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 10747009 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10747009}}
==About this Structure==
==About this Structure==
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[[Category: Rossman fold domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:12:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:53:50 2008''

Revision as of 21:53, 30 June 2008

Image:1ekj.png

Template:STRUCTURE 1ekj

THE X-RAY CRYSTALLOGRAPHIC STRUCTURE OF BETA CARBONIC ANHYDRASE FROM THE C3 DICOT PISUM SATIVUM

Template:ABSTRACT PUBMED 10747009

About this Structure

1EKJ is a Single protein structure of sequence from Pisum sativum. Full crystallographic information is available from OCA.

Reference

The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases., Kimber MS, Pai EF, EMBO J. 2000 Apr 3;19(7):1407-18. PMID:10747009

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