1el3

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{{STRUCTURE_1el3| PDB=1el3 | SCENE= }}
{{STRUCTURE_1el3| PDB=1el3 | SCENE= }}
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'''HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR'''
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===HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR===
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==Overview==
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The crystallographic structure of the complex between human aldose reductase (AR2) and one of its inhibitors, IDD384, has been solved at 1.7 A resolution from crystals obtained at pH 5.0. This structure shows that the binding of the inhibitor's hydrophilic head to the catalytic residues Tyr48 and His110 differs from that found previously with porcine AR2. The difference is attributed to a change in the protonation state of the inhibitor (pK(a) = 4.52) when soaked with crystals of human (at pH 5.0) or pig lens AR2 (at pH 6.2). This work demonstrates how strongly the detailed binding of the inhibitor's polar head depends on its protonation state.
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==About this Structure==
==About this Structure==
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[[Category: Diabetes]]
[[Category: Diabetes]]
[[Category: Inhibition]]
[[Category: Inhibition]]
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Revision as of 21:55, 30 June 2008

Image:1el3.png

Template:STRUCTURE 1el3

HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR

Template:ABSTRACT PUBMED 10771421

About this Structure

1EL3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human aldose reductase bound to the inhibitor IDD384., Calderone V, Chevrier B, Van Zandt M, Lamour V, Howard E, Poterszman A, Barth P, Mitschler A, Lu J, Dvornik DM, Klebe G, Kraemer O, Moorman AR, Moras D, Podjarny A, Acta Crystallogr D Biol Crystallogr. 2000 May;56(Pt 5):536-40. PMID:10771421

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