1elk

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{{STRUCTURE_1elk| PDB=1elk | SCENE= }}
{{STRUCTURE_1elk| PDB=1elk | SCENE= }}
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'''VHS domain of TOM1 protein from H. sapiens'''
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===VHS domain of TOM1 protein from H. sapiens===
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==Overview==
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VHS domains are found at the N-termini of select proteins involved in intracellular membrane trafficking. We have determined the crystal structure of the VHS domain of the human Tom1 (target of myb 1) protein to 1.5 A resolution. The domain consists of eight helices arranged in a superhelix. The surface of the domain has two main features: (1) a basic patch on one side due to several conserved positively charged residues on helix 3 and (2) a negatively charged ridge on the opposite side, formed by residues on helix 2. We compare our structure to the recently obtained structure of tandem VHS-FYVE domains from Hrs [Mao, Y., Nickitenko, A., Duan, X., Lloyd, T. E., Wu, M. N., Bellen, H., and Quiocho, F. A. (2000) Cell 100, 447-456]. Key features of the interaction surface between the FYVE and VHS domains of Hrs, involving helices 2 and 4 of the VHS domain, are conserved in the VHS domain of Tom1, even though Tom1 does not have a FYVE domain. We also compare the structures of the VHS domains of Tom1 and Hrs to the recently obtained structure of the ENTH domain of epsin-1 [Hyman, J., Chen, H., Di Fiore, P. P., De Camilli, P., and Brunger, A. T. (2000) J. Cell Biol. 149, 537-546]. Comparison of the two VHS domains and the ENTH domain reveals a conserved surface, composed of helices 2 and 4, that is utilized for protein-protein interactions. In addition, VHS domain-containing proteins are often localized to membranes. We suggest that the conserved positively charged surface of helix 3 in VHS and ENTH domains plays a role in membrane binding.
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{{ABSTRACT_PUBMED_10985773}}
==About this Structure==
==About this Structure==
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[[Category: Misra, S.]]
[[Category: Misra, S.]]
[[Category: Superhelix of helice]]
[[Category: Superhelix of helice]]
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Revision as of 21:56, 30 June 2008

Image:1elk.png

Template:STRUCTURE 1elk

VHS domain of TOM1 protein from H. sapiens

Template:ABSTRACT PUBMED 10985773

About this Structure

1ELK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes., Misra S, Beach BM, Hurley JH, Biochemistry. 2000 Sep 19;39(37):11282-90. PMID:10985773

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