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1eo0

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{{STRUCTURE_1eo0| PDB=1eo0 | SCENE= }}
{{STRUCTURE_1eo0| PDB=1eo0 | SCENE= }}
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'''CONSERVED DOMAIN COMMON TO TRANSCRIPTION FACTORS TFIIS, ELONGIN A, CRSP70'''
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===CONSERVED DOMAIN COMMON TO TRANSCRIPTION FACTORS TFIIS, ELONGIN A, CRSP70===
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==Overview==
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TFIIS is a transcription elongation factor that consists of three domains. We have previously solved the structures of domains II and III, which stimulate arrested polymerase II elongation complexes in order to resume transcription. Domain I is conserved in evolution from yeast to human species and is homologous to the transcription factors elongin A and CRSP70. Domain I also interacts with the transcriptionally active RNA polymerase II holoenzyme and therefore, may have a function unrelated to the previously described transcription elongation activity of TFIIS. We have solved the structure of domain I of yeast TFIIS using NMR spectroscopy. Domain I is a compact four-helix bundle that is structurally independent of domains II and III of the TFIIS. Using the yeast structure as a template, we have modeled the homologous domains from elongin A and CRSP70 and identified a conserved positively charged patch on the surface of all three proteins, which may be involved in conserved functional interactions with the transcriptional machinery.
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(as it appears on PubMed at http://www.pubmed.gov), where 10811649 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10811649}}
==About this Structure==
==About this Structure==
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1EO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EO0 OCA].
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1EO0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EO0 OCA].
==Reference==
==Reference==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:13:54 2008''

Revision as of 22:13, 30 June 2008

Image:1eo0.png

Template:STRUCTURE 1eo0

CONSERVED DOMAIN COMMON TO TRANSCRIPTION FACTORS TFIIS, ELONGIN A, CRSP70

Template:ABSTRACT PUBMED 10811649

About this Structure

1EO0 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70., Booth V, Koth CM, Edwards AM, Arrowsmith CH, J Biol Chem. 2000 Oct 6;275(40):31266-8. PMID:10811649

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