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1epb

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[[Image:1epb.gif|left|200px]]
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{{STRUCTURE_1epb| PDB=1epb | SCENE= }}
{{STRUCTURE_1epb| PDB=1epb | SCENE= }}
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'''STRUCTURE OF THE EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN AT 2.1 ANGSTROMS RESOLUTION'''
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===STRUCTURE OF THE EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN AT 2.1 ANGSTROMS RESOLUTION===
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==Overview==
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BACKGROUND: Androgen-dependent proteins in the lumen of the epididymis are required for sperm maturation. One of these is a retinoic acid binding protein, E-RABP, which binds both all-trans and 9-cis retinoic acid. The other retinoid-binding proteins whose structures are known do not bind 9-cis retinoids. RESULTS: We describe the X-ray structure determination of E-RABP with and without bound ligand. The ligand binds deep in the beta-barrel of the protein, the beta-ionone ring innermost. The binding site, like the ligand, is amphipathic and the deepest part of the cavity is formed by a ring of aromatic amino acids. The isoprene tail of all-trans retinoic acid is bound in a folded conformation which resembles that of the 9-cis isomer. CONCLUSION: E-RABP achieves high-affinity binding of both all-trans and 9-cis isomers of retinoic acid by forcing the all-trans form to bind in a folded conformation. The RAR family of nuclear receptors for retinoic acid also binds both isomers, and their binding sites may therefore be similar.
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(as it appears on PubMed at http://www.pubmed.gov), where 8069623 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8069623}}
==About this Structure==
==About this Structure==
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[[Category: Newcomer, M E.]]
[[Category: Newcomer, M E.]]
[[Category: Retinoic acid-binding protein]]
[[Category: Retinoic acid-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:22:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:28:48 2008''

Revision as of 22:29, 30 June 2008

Image:1epb.png

Template:STRUCTURE 1epb

STRUCTURE OF THE EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN AT 2.1 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8069623

About this Structure

1EPB is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the epididymal retinoic acid binding protein at 2.1 A resolution., Newcomer ME, Structure. 1993 Sep 15;1(1):7-18. PMID:8069623

Page seeded by OCA on Tue Jul 1 01:28:48 2008

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