1epb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1epb.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1epb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1epb| PDB=1epb | SCENE= }}
{{STRUCTURE_1epb| PDB=1epb | SCENE= }}
-
'''STRUCTURE OF THE EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN AT 2.1 ANGSTROMS RESOLUTION'''
+
===STRUCTURE OF THE EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN AT 2.1 ANGSTROMS RESOLUTION===
-
==Overview==
+
<!--
-
BACKGROUND: Androgen-dependent proteins in the lumen of the epididymis are required for sperm maturation. One of these is a retinoic acid binding protein, E-RABP, which binds both all-trans and 9-cis retinoic acid. The other retinoid-binding proteins whose structures are known do not bind 9-cis retinoids. RESULTS: We describe the X-ray structure determination of E-RABP with and without bound ligand. The ligand binds deep in the beta-barrel of the protein, the beta-ionone ring innermost. The binding site, like the ligand, is amphipathic and the deepest part of the cavity is formed by a ring of aromatic amino acids. The isoprene tail of all-trans retinoic acid is bound in a folded conformation which resembles that of the 9-cis isomer. CONCLUSION: E-RABP achieves high-affinity binding of both all-trans and 9-cis isomers of retinoic acid by forcing the all-trans form to bind in a folded conformation. The RAR family of nuclear receptors for retinoic acid also binds both isomers, and their binding sites may therefore be similar.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8069623}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8069623 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8069623}}
==About this Structure==
==About this Structure==
Line 24: Line 28:
[[Category: Newcomer, M E.]]
[[Category: Newcomer, M E.]]
[[Category: Retinoic acid-binding protein]]
[[Category: Retinoic acid-binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:22:30 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:28:48 2008''

Revision as of 22:29, 30 June 2008

Image:1epb.png

Template:STRUCTURE 1epb

STRUCTURE OF THE EPIDIDYMAL RETINOIC ACID-BINDING PROTEIN AT 2.1 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8069623

About this Structure

1EPB is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the epididymal retinoic acid binding protein at 2.1 A resolution., Newcomer ME, Structure. 1993 Sep 15;1(1):7-18. PMID:8069623

Page seeded by OCA on Tue Jul 1 01:28:48 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1epb"
Personal tools