1eq7

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{{STRUCTURE_1eq7| PDB=1eq7 | SCENE= }}
{{STRUCTURE_1eq7| PDB=1eq7 | SCENE= }}
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'''CORE STRUCTURE OF THE OUTER MEMBRANE LIPOPROTEIN FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION'''
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===CORE STRUCTURE OF THE OUTER MEMBRANE LIPOPROTEIN FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION===
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==Overview==
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The outer membrane lipoprotein of the Escherichia coli cell envelope has characteristic lipid modifications at an amino-terminal cysteine and can exist in a form bound covalently to the peptidoglycan through a carboxyl-terminal lysine. The 56-residue polypeptide moiety of the lipoprotein, designated Lpp-56, folds into a stable, trimeric helical structure in aqueous solution. The 1.9 A resolution crystal structure of Lpp-56 comprises a parallel three-stranded coiled coil including a novel alanine-zipper unit and two helix-capping motifs. The amino-terminal motif forms a hydrogen-bonding network anchoring an umbrella-shaped fold. The carboxyl-terminal motif uses puckering of the tyrosine side-chains as a unique docking arrangement in helix termination. The structure provides an explanation for assembly and insertion of the lipoprotein molecules into the outer membrane of gram-negative bacteria and suggests a molecular target for antibacterial drug discovery.
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(as it appears on PubMed at http://www.pubmed.gov), where 10843861 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10843861}}
==About this Structure==
==About this Structure==
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[[Category: Outer membrane]]
[[Category: Outer membrane]]
[[Category: Protein folding]]
[[Category: Protein folding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:23:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:39:20 2008''

Revision as of 22:39, 30 June 2008

Image:1eq7.png

Template:STRUCTURE 1eq7

CORE STRUCTURE OF THE OUTER MEMBRANE LIPOPROTEIN FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 10843861

About this Structure

1EQ7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Core structure of the outer membrane lipoprotein from Escherichia coli at 1.9 A resolution., Shu W, Liu J, Ji H, Lu M, J Mol Biol. 2000 Jun 16;299(4):1101-12. PMID:10843861

Page seeded by OCA on Tue Jul 1 01:39:20 2008

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