1eq8

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[[Image:1eq8.gif|left|200px]]
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{{STRUCTURE_1eq8| PDB=1eq8 | SCENE= }}
{{STRUCTURE_1eq8| PDB=1eq8 | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE PENTAMERIC HELICAL BUNDLE OF THE ACETYLCHOLINE RECEPTOR M2 TRANSMEMBRANE SEGMENT'''
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===THREE-DIMENSIONAL STRUCTURE OF THE PENTAMERIC HELICAL BUNDLE OF THE ACETYLCHOLINE RECEPTOR M2 TRANSMEMBRANE SEGMENT===
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==Overview==
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The structures of functional peptides corresponding to the predicted channel-lining M2 segments of the nicotinic acetylcholine receptor (AChR) and of a glutamate receptor of the NMDA subtype (NMDAR) were determined using solution NMR experiments on micelle samples, and solid-state NMR experiments on bilayer samples. Both M2 segments form straight transmembrane alpha-helices with no kinks. The AChR M2 peptide inserts in the lipid bilayer at an angle of 12 degrees relative to the bilayer normal, with a rotation about the helix long axis such that the polar residues face the N-terminal side of the membrane, which is assigned to be intracellular. A model built from these solid-state NMR data, and assuming a symmetric pentameric arrangement of M2 helices, results in a funnel-like architecture for the channel, with the wide opening on the N-terminal intracellular side.
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(as it appears on PubMed at http://www.pubmed.gov), where 10201407 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10201407}}
==About this Structure==
==About this Structure==
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1EQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQ8 OCA].
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1EQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQ8 OCA].
==Reference==
==Reference==
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[[Category: Neurotransmitter receptor]]
[[Category: Neurotransmitter receptor]]
[[Category: Pentameric bundle]]
[[Category: Pentameric bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:24:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:39:26 2008''

Revision as of 22:39, 30 June 2008

Image:1eq8.png

Template:STRUCTURE 1eq8

THREE-DIMENSIONAL STRUCTURE OF THE PENTAMERIC HELICAL BUNDLE OF THE ACETYLCHOLINE RECEPTOR M2 TRANSMEMBRANE SEGMENT

Template:ABSTRACT PUBMED 10201407

About this Structure

1EQ8 is a Single protein structure of sequence from Torpedo californica. Full experimental information is available from OCA.

Reference

Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy., Opella SJ, Marassi FM, Gesell JJ, Valente AP, Kim Y, Oblatt-Montal M, Montal M, Nat Struct Biol. 1999 Apr;6(4):374-9. PMID:10201407

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