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1eqf

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[[Image:1eqf.gif|left|200px]]
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{{STRUCTURE_1eqf| PDB=1eqf | SCENE= }}
{{STRUCTURE_1eqf| PDB=1eqf | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250'''
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===CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250===
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==Overview==
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TFIID is a large multiprotein complex that initiates assembly of the transcription machinery. It is unclear how TFIID recognizes promoters in vivo when templates are nucleosome-bound. Here, it is shown that TAFII250, the largest subunit of TFIID, contains two tandem bromodomain modules that bind selectively to multiply acetylated histone H4 peptides. The 2.1 angstrom crystal structure of the double bromodomain reveals two side-by-side, four-helix bundles with a highly polarized surface charge distribution. Each bundle contains an Nepsilon-acetyllysine binding pocket at its center, which results in a structure ideally suited for recognition of diacetylated histone H4 tails. Thus, TFIID may be targeted to specific chromatin-bound promoters and may play a role in chromatin recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 10827952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10827952}}
==About this Structure==
==About this Structure==
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[[Category: Acetylated histone-tail binding protein]]
[[Category: Acetylated histone-tail binding protein]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:24:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:40:51 2008''

Revision as of 22:40, 30 June 2008

Image:1eqf.png

Template:STRUCTURE 1eqf

CRYSTAL STRUCTURE OF THE DOUBLE BROMODOMAIN MODULE FROM HUMAN TAFII250

Template:ABSTRACT PUBMED 10827952

About this Structure

1EQF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and function of a human TAFII250 double bromodomain module., Jacobson RH, Ladurner AG, King DS, Tjian R, Science. 2000 May 26;288(5470):1422-5. PMID:10827952

Page seeded by OCA on Tue Jul 1 01:40:51 2008

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